CJEM Articles: Colleen B. Kjelland

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  • The use of tranexamic acid for trauma patients?
    January 2012 14 1
    Bryan J. Weber, BScN, Colleen B. Kjelland

    Clinical Question

    Does giving tranexamic acid to trauma patients who are actively bleeding or at risk for significant hemorrhage have an impact on mortality?

    Article Chosen

    CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32.

    Objective

    The study collaborators sought to evaluate the effect of tranexamic acid on mortality in trauma patients who were actively bleeding or at risk for significant hemorrhage. Secondary outcomes included the incidence of vascular occlusive events and the number of blood transfusions required.