CJEM Articles: Shirra Cremer
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Successful treatment of pediatric stroke with recombinant tissue plasminogen activator (rt-PA): a case report and review of the literatureNovember 2008 10 6Andrew E. Jones, David Warren, Shirra Cremer, Yaniv Berliner
Pediatric stroke is a rare disorder with a paucity of evidence-based treatment options, and can result in significant morbidity and mortality. In contrast to adult acute ischemic stroke, where the use of recombinant tissue plasminogen activator (rt-PA) has been studied in several large, randomized clinical trials, no high-level evidence exists for the use of thrombolytics in children with stroke. We report a case of a 15-year-old girl who suffered an acute ischemic stroke and had a dramatic improvement in symptoms following the administration of intravenous rt-PA.